Changes in fMRI connectivity after treatment for paranoia

Prior research suggests that resting state functional magnetic resonance imaging (fMRI) connectivity between the amygdala (a brain structure related to threat perception) and the visual cortex is associated with paranoia. As part of the ongoing evaluation of the computer-based treatment Coping with Paranoia, I am examining pre- and post-treatment resting state connectivity in people with serious mental illness participating in the treatment to evaluate whether reductions in amygdala-visual cortex connectivity is associated with reductions in paranoia symptoms.